Cevap: Bazı hastalarda; ilaç, fizik tedavi, girişimsel ağrı uygulamaları ve altta yatan nedene yönelik tedavilere rağmen şiddetli ve işlev kaybettiren ağrı sürerse; seçilmiş durumlarda nöromodülasyon (omurilik pili) veya morfin pompası gibi yöntemler bir seçenek olabilir. Bu yöntemler her hastaya uygun değildir; karar tanı, risk–yarar ve hedeflere göre verilir.
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